In an initial RNA world, Protein would have tended to gather around RNA. Nucleic acid binding as one of the oldest traits of proteins. Going over to more protein-based function, did evolution proceed by create proteins that substituted for central RNA/DNA. Scaffolding proteins as replacement? Protein signalling complexes evolved from protein-Nuc. acid complexes? Look for similarities in Nuc. acid binding features and protein-protein interactions. Maybe it's not directly linear in evolution, but more as a derived feature, using already existing traits. Signallosomes as loose ribyzymes?
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