Party Signalling II

... cont: but if cellular signalling events are like parties, then maybe one could use parties to describe and learn about signalling events. Choose the right descriptors, record party, match party descriptors to characteristics of known signalling events, identify best matching signalling event, and then use party dynamics to learn about best matching signalling event (complete, extrapolate, test hypothesis). "After the third drink, Sue sat on the couch to chill; this attracted quickly Pete, Jo and Matt. Sue would have preferred to chat with the cute Ben, but he was off wiggling his bum to impress Amy. But Pete was quite funny tonight, so she sat down for a while and listened; Matt thought some more drinks might help getting things going, and went off to fetch some from the fridge. This however perturbed the starting love affair between Jean and Nelly; Nelly had to leave just thereafter, and went to Singapore next day without exchanging email addresses with Jean. As a result they did not get married, her son Kevin was not born and could not save London from a fatal bio-gas attack forty years later." Maybe this matches to T cell receptor signalling? I guess we will learn to appreciate the importance of the unspectacular parties, and signalling events, to keep up criticallity.

blinded by the Light

Why is it that all sorts of night-active insects fly straight into light sources? Being programmed to be active at night, attraction to light does not make any sense. If they strive for light, they could just fly during the day. And wouldn't there be the danger of just trying to fly straight into the full moon on a clear night? Is that a hint that nocturnal insects have evolved from diurnal ones? And why has no insectivorous species developed light sources - like deep-see fish - to easily capture all these badly programmed prey?

Car fusion

It was shown that a mean human face (i.e. where all measures between and for facial features are the set to those corresponding to the average values of human populations) is beautiful. If one averages the 20 % of the most beautiful faces, then the average top20% beautiful face is perceived as being even more beautiful than just the average face. If one then calculates the vectorial distance between the 'average' and the 'top20% average' face, and uses the same vector to 'exaggerate' the top20% average, then the top20% + average face is even more beautiful than the top20% face. All this to say that one should use the same algorithm to conceive car profiles, and built the most beautiful vehicle of all - very simply. If that works for car profiles, then maybe other objects could be tackled, too.

Party Signalling

Cellular signal transduction was initially viewed as a kind of chinese whisper. A talks to B who goes off to talk to C who switches on the light. Others are not concerned. I guess however signal transduction it's more like a party. Who ever is there will talk. Duration of the interaction will depend on compatibility and personal predisposition. If by chance there is THE FUNNY GUY, or THE PERFECT GIRL, then people will congregate. If not, then someone else will tell jokes or be pulled, however only moderately, depending on how much alcohol. An evening with three moderately funny guys might still be very enjoyable. Most parties finish in a rather unspectacular way. The likeliness for a spectacular outcome (e.g. Gilles dancing naked on the table) will depend on the sum of all attractions plus personal predisposition plus some energetic fluctuations. It's about functional redundancy and compensation, criticallity.

Top Score

The saddest species of all: 70+ year old poor Caucasians.

Random Hacking

Having said this, I have never really tried, so let's go:
diosqsokdf qsd zpzei vfdsidijhrtnzscqbbq olzd zer csdqsqdoihze sqdoihr sdfzezownbvvbnzqp^sdk poffezearesaqrit mlsdvxsor qsf te ar enfdsqio mdiogz elfiojq zqf goot aiodf bbsdeioropa sdfg poiuicerea oirea sfdz p tezhsioc pojz lishe as froa shu.
... well maybe not this time, unless it means something awfully beautiful in wolof. However, I guess it just shows how long 1 million years are.

Inbalance

On one side of the globe there are so many in need of so much, while on the other side of the globe educated persons get depressed because there is no sense to their lives. What do we learn from that?

Biotristesse

There is something wrong with organic (food) shops. They are just not funny. Neither the people, nor the lay-out. Rather than meeting a happy folk eating healthy food, I see a bunch of grumpy and frustrated people, aged 35+, cruising though austere food rows. There is something like a silent accusation in the air. I wonder why.

3-Dimensional Language

Language is a tedious thing. I've always these wonderfully meaningful 3D picture of things (objects, issues, facts) and their links (causal, temporal, spatial) in my mind. It's all clear and reassuringly contained. But to communicate this 'sensogram', I need to squeeze it into the one-dimensional tube that is our language. Too much reduction, so much frustration, and a lot of misunderstanding. We really need a 3D communication system!